报告题目： Targeting metabolic vulnerabilities for development of new antimicrobials
报 告 人： Choukri Ben Mamoun，Ph.D.
Professor of Medicine and Microbial Pathogenesis
Yale School of Medicine
Department of Internal Medicine
& Department of Microbial Pathogenesis
时 间： 2019 年 10 月 19 日（星期六）上午 10:00-11:00
地 点： 生化楼三层中厅
主 持 人： 鲁凤民 教授
The Ben Mamoun Lab at Yale University focuses on understanding how pathogens import and utilize host nutrients for development, differentiation, and virulence. They focus on two important human diseases, malaria and babesiosis caused by protozoan parasites of the genus Plasmodium and Babesia, respectively. The lecture will be divided into two part: First, Prof. Ben Mamoun will describe studies that link metabolism of phospholipids to malaria development and pathogenesis. Specifically, he will present biochemical, genetic and structural data on an important lipid metabolic enzyme and efforts to target it for the development of new classes of antimicrobials. Second, Prof. Ben Mamoun will present a recent discovery in the lab of a novel mechanism by which Babesia parasites export proteins to the host, and strategies developed to discover new antiparasitic drugs.